Compazine is a prescription medicine used to treat the symptoms of psychosis and severe nausea or vomiting. It can treat nausea and vomiting. It can also treat anxiety and schizophrenia. Several antiemetics have been considered for migraine management, including metoclopramide, domperidone, and prochlorperazine.
Oral and rectal formulations of indomethacin/prochlorperazine/caffeine provide a further option in the acute treatment of migraine and in the treatment of episodic TTH in adult patients.
Becker WJ. Acute Migraine Treatment in Adults. Headache. 2015 Jun;55(6):778-93. doi: 10.1111/head.12550. Epub 2015 Apr 15. PMID: 25877672.
Hoy SM, Scott LJ. Indomethacin/prochlorperazine/caffeine: a review of its use in the acute treatment of migraine and in the treatment of episodic tension-type headache. CNS Drugs. 2011 Apr;25(4):343-58. doi: 10.2165/11206740-000000000-00000. PMID: 21425885.