Cyproheptadine (5HT2 antagonist) is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It has been described as a possible prescription for pediatric migraine.
Abdominal migraine is a syndrome characterized by recurrent stereotypic episodes of paroxysmal abdominal pain and nausea and/or vomiting with wellness between episodes. It is often associated with a positive family history of migraine and no other apparent underlying disease. Patients with abdominal migraine may benefit from prophylactic treatment with propranolol or cyproheptadine. (Worawattanakul, 1999)
From review of available evidence, the most efficacious acute treatments of paediatric migraine include the non-steroidal anti-inflammatory agent ibuprofen at 7.5 - 10 mg/kg/dose or nasal sumatriptan at doses of 5 or 20 mg. For those patients with headaches that occur with sufficient frequency and severity to warrant daily prophylaxis, controlled data are limited. Agents which are likely to be beneficial include amitriptyline, flunarizine (not available in the US) and cyproheptadine. (Lewis, 2002)
Daily dose of 12 to 16 mg.
Worawattanakul M, Rhoads JM, Lichtman SN, Ulshen MH. Abdominal migraine: prophylactic treatment and follow-up. J Pediatr Gastroenterol Nutr. 1999 Jan;28(1):37-40. doi: 10.1097/00005176-199901000-00010. PMID: 9890466.
Lewis DW, Scott D, Rendin V. Treatment of paediatric headache. Expert Opin Pharmacother. 2002 Oct;3(10):1433-42. doi: 10.1517/14656566.3.10.1433. PMID: 12387689.